Naoko Isami 伊佐未直子

As the matriarch of the Isami household, she is Yu's caring and loving grandmother. Even though she resents her son and daughter-in-law's research on using their children as initial "vessels" for the Antibodies, she was able to give her own wisdom to Yu. She is the long lost lover of Winston Geybridge and until now she still is close to him.